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This methylation profile is by now acquired at the MBL stage3 and remains comparatively steady after a while. On the other hand, some CLL have intratumor variability in sure locations, which can alter the expression of numerous genes and facilitate tumor evolution.71 Of Be aware, this variability is greater in U-CLL than in M-CLL and it is connected with growing range of subclones.7,seventy one
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mutations and sophisticated kar yotype. It follows a linear evolution from your CLL clone in the recurrent acquisition of CDKN2A